Association BetweenGlycemia and Mortality in Diabetic Individuals on Renal Replacement Therapy in the United Kingdom

Using national UK Renal Registry data, we tested whether glycemia as measured by hemoglobin (Hb) A1c (HbA1c) level is associated with death in adults with diabetes starting hemodialysis or peritoneal dialysis between 1997 and 2006, and observed for at least 6months. Of 7,814 patients, we excluded thosewho had died within 6 months; had received transplants; were lost/recovered; or lacked measures of HbA1c, ethnicity, or Hb. Categorizing HbA1c measured in the first 6 months of starting dialysis as <6.5% (<48mmol/mol), 6.5–7.4% (48–57mmol/mol) (reference value), 7.5–8.4% (58–68 mmol/mol), and ‡8.5% (‡69 mmol/mol), we adjusted in proportional hazards models for age, sex, ethnicity, deprivation, year, dialysis type, and Hb, and tested for interactions.